Related Experiment Video
Updated: May 31, 2026
Using Micro-computed Tomography for the Assessment of Tumor Development and Follow-up of Response to Treatment in a Mouse Model of Lung Cancer
Published on: May 20, 2016
Evolution of pulmonary function after treatment with goserelin in patients with lymphangioleiomyomatosis
Bruno Guedes Baldi1, Pedro Medeiros Junior, Suzana Pinheiro Pimenta
1Department of Pulmonology, Instituto do Coração - InCor, Heart Institute - and in the Department of Urology, University of São Paulo School of Medicine Hospital das Clínicas, São Paulo, Brazil. bruno.guedes2@terra.com.br
Abstract:
In the atypical smooth muscle cells that are characteristic of lymphangioleiomyomatosis (LAM), there are estrogen and progesterone receptors. Therefore, anti-hormonal therapy, despite having produced controversial results, can be considered a treatment option. The objective of this retrospective study was to evaluate hormonal and spirometric data for nine women with LAM after one year of treatment with goserelin. The mean increase in FEV1 and FVC was 80 mL and 130 mL, respectively. There was effective blockage of the hormonal axis. It is still not possible to exclude a potential beneficial effect of the use of gonadotropin-releasing hormone analogues in LAM patients, which underscores the need for randomized trials.
