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Related Experiment Video

Updated: May 31, 2026

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

Omentin-1 exerts bone-sparing effect in ovariectomized mice.

H Xie1, P-L Xie, X-H Luo

  • 1Institute of Endocrinology and Metabolism, Second Xiangya Hospital of Central South University, 139# Middle Renmin Road, Changsha, Hunan 410011, People's Republic of China.

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
|July 15, 2011
PubMed
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Omentin-1, a cytokine, was found to inhibit osteoblast differentiation and reduce osteoclast formation by modulating OPG and RANKL. This suggests omentin-1 may protect against bone loss from estrogen deficiency.

Area of Science:

  • Endocrinology
  • Bone Biology
  • Metabolic Research

Background:

  • Omentin-1 (intelectin-1) is a visceral adipose tissue-derived cytokine abundant in plasma.
  • Its role in bone metabolism was previously uncharacterized.

Purpose of the Study:

  • To investigate the effects of omentin-1 on bone metabolism.
  • To determine omentin-1's potential in ameliorating bone loss.

Main Methods:

  • In vitro assessment of osteoblast differentiation and osteoclast formation.
  • Co-culture systems of osteoblasts and osteoclast precursors.
  • In vivo studies using adenovirus-mediated omentin-1 delivery in ovariectomized mice.

Main Results:

  • Omentin-1 inhibited osteoblast differentiation in vitro.

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Last Updated: May 31, 2026

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  • Omentin-1 reduced osteoclast formation by increasing osteoprotegerin (OPG) and decreasing receptor activator for nuclear factor κB ligand (RANKL) production in osteoblasts.
  • Adenovirus-mediated omentin-1 overexpression in vivo restored bone mineral density and bone strength in ovariectomized mice.

    • Conclusions:

    • Omentin-1 ameliorates bone loss associated with estrogen deficiency.
    • This effect is mediated by downregulating the RANKL/OPG ratio.