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Updated: May 31, 2026

Static Strength Training Method for Type 2 Diabetic Mice
Published on: March 29, 2024
Motor nerve decline does not underlie muscle weakness in type 2 diabetic neuropathy
T Herman Ijzerman1, Nicolaas C Schaper, Tom Melai
1Department of Movement Sciences, Nutrition and Toxicology, Research Institute Maastricht, Faculty Health, Medicine and Life Sciences, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands. herman.ijzerman@maastrichtuniversity.nl
Introduction:
Type 2 diabetes mellitus (DM2) patients may have decreased muscle strength. This decline can have multiple causes, among them diabetic polyneuropathy (DPN). We sought to determine the effect of nerve deterioration on muscle strength in DM2 patients with and without DPN.
Methods:
Nineteen DM2 patients with DPN (DPN group), 15 DM2 patients without DPN (DC group), and 18 healthy subjects (HC group) were recruited. We determined motor and sensory nerve function of the lower extremity. Isometric dynamometry was performed to determine maximum torque of the ankle joint.
Results:
The DPN group had significantly diminished nerve function and muscle strength (P < 0.05) compared with both other groups. Only muscle strength was lower in DC subjects compared with HCs. No significant correlations were found between nerve function and muscle strength.
Conclusion:
These results indicate that reduced ankle joint torque in DM2 patients with and without DPN is independent of the presence of disturbed nerve function.
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