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Updated: May 31, 2026
07:56
Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
Published on: January 29, 2018
Bone geometry profiles in women with and without SLE
Jimmy D Alele1, Diane L Kamen, Kelly J Hunt
1Division of Endocrinology, Diabetes and Medical Genetics, Charleston, SC, USA. alele@musc.edu
Summary
Systemic lupus erythematosus (SLE) is linked to poorer bone geometry, increasing fracture risk in women. This study found lower bone density and altered hip structure in SLE patients compared to controls.
Area of Science:
- Rheumatology
- Orthopedics
- Bone Biology
Background:
- Systemic lupus erythematosus (SLE) is associated with an elevated fracture risk compared to the general population.
- Understanding bone geometry in SLE is crucial for assessing fracture susceptibility.
Purpose of the Study:
- To investigate the associations between SLE status and hip bone geometry in white and African-American women.
- To compare bone mineral density (BMD) and bone geometry parameters between SLE patients and control individuals.
Main Methods:
- Utilized hip structure analysis (HSA) on dual-energy X-ray absorptiometry (DXA) scans from two cohorts.
- Analyzed data from 153 SLE patients and 4920 controls, adjusting for age and BMI using linear regression.
- Examined differences in BMD and bone geometry by SLE status and race/ethnicity.
Main Results:
- Significant differences in bone geometry were observed between SLE women and controls across all hip subregions.
- SLE women, regardless of race, exhibited lower BMD, section modulus, and cross-sectional areas.
- Buckling ratios were increased in SLE women, indicating a potential for increased bone fragility.
Conclusions:
- Bone geometry profiles in SLE patients suggest a higher risk of bone fragility and fractures.
- These findings highlight the importance of assessing bone health in SLE management.
- Racial differences in bone geometry between SLE and control groups warrant further investigation.
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