Some new psychoactive substances: precursor chemicals and synthesis-driven end-products

This paper describes some of the new classes of 'designer drugs' being encountered today by forensic scientists and law enforcement agencies in Europe, the United States, and Australia. In particular, it concentrates on new cathinone derivatives, the tryptamines, new-generation phenethylamines, and some of the synthetic cannabinoids. The synthetic approaches towards many of these designer drugs including a discussion of the chemical precursors used in the syntheses are presented. Many of today's so-called designer drugs exist as a result of legitimate research into medical conditions and the natural product chemistry. A link between synthetic approaches published in the open scientific and medical literature and the exploitation of this research by clandestine manufacture of drugs for illicit purposes is drawn.