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Updated: May 31, 2026

Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings

Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings

Published on: October 25, 2015

Developmental programming of the ovine placenta.

A L Fowden¹, J W Ward, F B P Wooding

¹Department of Physiology, Development & Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK. alf1000@cam.ac.uk

Society of Reproduction and Fertility Supplement

|July 16, 2011

Summary

This summary is machine-generated.

Early life nutrition and placental development influence adult health. The placenta epigenome remembers environmental exposures, impacting offspring well-being and disease risk.

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Area of Science:

Reproductive biology
Developmental programming
Epigenetics

Background:

Intrauterine growth and birth size impact later-life tissue function and adult-onset diseases.
Placental nutrient supply is key to mammalian intrauterine growth, but placental development is poorly understood.
Epigenetic regulation of the placenta is crucial for fetal development.

Purpose of the Study:

To review the epigenetic regulation of placental phenotype.
To emphasize nutrient transfer capacity in the ovine placenta.
To explore environmental factors influencing placental developmental programming.

Main Methods:

Literature review focusing on epigenetic mechanisms.
Analysis of ovine placental models.
Examination of environmental influences on placental development.

Main Results:

The placenta is responsive to environmental factors, adapting its phenotype to support fetal growth.
Placental nutrient supply capacity is dynamically altered, not passive.
The placental epigenome records developmental environmental conditions.

Conclusions:

The placenta actively modifies nutrient supply to optimize fetal acquisition.
The placental epigenome serves as a memory of developmental exposures.
Placental epigenetics indicate offspring's future health outcomes.