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Updated: May 31, 2026
Technique of Porcine Liver Procurement and Orthotopic Transplantation using an Active Porto-Caval Shunt
Published on: May 7, 2015
Correlation between rotation thrombelastometry ROTEM analysis and standard haemostatic parameters during liver
Assia Stancheva1, Lubomir Spassov, Kamen Tzatchev
1University Hospital "Lozenetz", Sofia, Bulgaria. assiastancheva@yahoo.com
Background:
The determination of the correlations between simultaneously performed rotation thrombelastometry ROTEM analysis and standard haemostatic analysis during liver transplantations is indispensable for performing an adequate perioperative haemostatic monitoring.
Methods:
Perioperative haemostatic monitoring was performed to 30 patients undergoing orthotopic liver transplantation (13 male (42%) and 17 female (58%), age: (mean +/- SD; 21 +/- 17 years). Standard coagulation parameters (PT, APTT, FIB) were assessed chronometrically on STA-Compact Analyzer (Diagnostica Stago - La Roche), rotation thrombelastometry analyses - on ROTEM analyzer (Petapharm GmbH) and platelets (PLT) - on Cell Dyn 3700 (Abbott Diagnostica), MAPSS technology.
Results:
A protocol was successfully developed for the implementation of perioperative haemostatic control during orthotopic liver transplantations, performing parallel thrombelastometric and standard haemostatic analyses. Significant correlation was established between PT(INR) and EXTEM_CFT ( r = 0.834; p < 0.001) and between APTT and INTEM_CFT (r = 0.707; p < 0.001) in the preoperative period (R1). The correlation was reduced to insignificant during the intraoperative periods (R2-R5) and two hours postoperatively (R6). Significant correlation was determined between PLT/INTEM and between FIB/MCF_FIBTEM during all perioperative periods (R1 -R6).
Conclusions:
The correlations found in the present study suggest to perform the haemoststic liver transplantation monitoring through a parallel systematic analysis of both standard and rotation thrombelastometry parameters and confirm the ROTEM method as preferable and highly informative.
