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Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

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Related Experiment Video

Updated: May 31, 2026

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts
09:20

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts

Published on: June 26, 2018

From the sea to anticancer therapy.

P Russo1, C Nastrucci, A Cesario

  • 1IRCCS "San Raffaele Pisana", Via di Valcannuta 247, I-00166 Roma, Italy. patrizia_russo@hotmail.it

Current Medicinal Chemistry
|July 16, 2011
PubMed
Summary
This summary is machine-generated.

Nature provides a rich source of potential anticancer drugs from marine organisms. Advances in biotechnology enable the discovery, characterization, and clinical evaluation of these novel marine-derived chemotherapy agents.

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Last Updated: May 31, 2026

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts
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Area of Science:

  • Marine biotechnology
  • Pharmacology
  • Drug discovery

Background:

  • Nature has historically been a vital source of medicinal agents.
  • Marine environments, including deep and shallow waters, harbor immense chemical diversity.
  • Marine organisms have evolved potent biologically active compounds, often toxins, for survival.

Purpose of the Study:

  • To review the discovery and development of marine-derived drugs for cancer chemotherapy.
  • To describe the mode of action of these novel anticancer agents.
  • To outline their current and potential clinical applications.

Main Methods:

  • Review of scientific literature on marine natural products.
  • Analysis of advancements in biotechnological tools for drug discovery.
  • Examination of preclinical and clinical trial data for marine-derived anticancer drugs.

Main Results:

  • Marine organisms represent a promising frontier for novel anticancer drug discovery.
  • Technological progress facilitates the isolation, characterization, and synthesis of marine compounds.
  • Several marine-derived compounds are undergoing or have completed clinical evaluation.

Conclusions:

  • Marine natural products offer a significant potential for developing new cancer chemotherapies.
  • Continued exploration and technological innovation are key to unlocking this potential.
  • Marine-derived drugs are expected to play an increasing role in cancer treatment.