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Updated: May 31, 2026

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
Published on: December 9, 2015
Detection of putative new mutacins by bioinformatic analysis using available web tools
1Département de Biochimie Microbiologie et Bioinformatique, Faculté des Sciences et Génie, Université Laval, Québec (Québec), G1K7P4, Canada. guillaume.nicolas.1@ulaval.ca.
Abstract:
In order to characterise new bacteriocins produced by Streptococcus mutans we perform a complete bioinformatic analyses by scanning the genome sequence of strains UA159 and NN2025. By searching in the adjacent genomic context of the two-component signal transduction system we predicted the existence of many putative new bacteriocins' maturation pathways and some of them were only exclusive to a group of Streptococcus. Computational genomic and proteomic analysis combined to predictive functionnal analysis represent an alternative way for rapid identification of new putative bacteriocins as well as new potential antimicrobial drugs compared to the more traditional methods of drugs discovery using antagonism tests.
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