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Updated: May 31, 2026

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Published on: April 6, 2022

Interleukin-10 polymorphisms and tuberculosis susceptibility: a meta-analysis.

J Zhang¹, Y Chen, X-B Nie

¹Key Laboratory of Laboratory Medicine, Ministry of Education, Zhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou Medical College, Wenzhou, Zhejiang, China.

The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease

|July 16, 2011

Summary

Interleukin 10 (IL-10) gene polymorphisms are linked to tuberculosis (TB) risk. A meta-analysis found the -1082G/A polymorphism may increase TB risk in European populations.

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Last Updated: May 31, 2026

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Published on: April 6, 2022

Area of Science:

Immunogenetics
Infectious Diseases
Genetic Epidemiology

Background:

Interleukin 10 (IL-10) gene polymorphisms are studied for their association with tuberculosis (TB) susceptibility.
Previous research yielded inconsistent and inconclusive findings regarding this link.

Purpose of the Study:

To conduct a meta-analysis investigating the association between IL-10 gene polymorphisms and TB susceptibility.
To clarify the role of specific IL-10 polymorphisms in TB risk.

Main Methods:

A meta-analysis was performed on 18 studies.
Examined three IL-10 gene polymorphisms: -1082G/A, -819C/T, and -592A/C.
Subgroup analysis was conducted based on ethnicity.

Main Results:

Overall, no significant association was found between the three IL-10 polymorphisms and TB risk in combined analyses.
However, subgroup analysis revealed that European subjects with -1082(AA+GG) genotypes had a decreased risk of TB (OR 0.55, P=0.01).

Conclusions:

The -1082G/A polymorphism of the IL-10 gene may be a risk factor for TB specifically in European populations.
Further large-scale studies are needed to confirm the association between IL-10 polymorphisms and TB susceptibility.