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Updated: May 31, 2026

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
Published on: August 16, 2021
Did the 'Great Recession' produce a depression in tuberculosis incidence?
D P Holland1, A K Person, J E Stout
1Department of Medicine, Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina 27713, USA. david.p.holland@duke.edu
Abstract:
In 2009, the United States experienced a record drop in its tuberculosis (TB) case rate, coinciding with a major economic downturn. To investigate this relationship, we modeled short-term changes in gross domestic product, unemployment, and immigration as predictors of TB incidence. We also correlated each state's 2009-2010 change in unemployment with its 2008-2009 change in TB incidence. Although economic factors did not explain the decline, the 2009-2010 change in unemployment negatively correlated with incidence. We hypothesize that factors related to increased unemployment, such as diagnostic delay, may have played a role in the sudden drop in TB case rates.
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