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Ophthalmic Drug Delivery Systems01:23

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Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
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Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome
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[Tear osmolarity and dry eye].

Shi-yin Pan1, Xiang-hua Xiao, Yang-zheng Wang

  • 1Department of Ophthalmology, the First Hospital of Xi'an, Shaanxi Key Laboratory of Ophthalmology, Shaanxi Institute of Ophthalmology, Xi'an 710002, China. panshiyin@163.com

[Zhonghua Yan Ke Za Zhi] Chinese Journal of Ophthalmology
|July 16, 2011
PubMed
Summary
This summary is machine-generated.

Increased tear osmolarity is a key factor in dry eye disease. New testing methods enable better diagnosis and treatment, including the potential of hypotonic artificial tears for managing dry eye symptoms.

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Area of Science:

  • Ophthalmology
  • Biomedical Engineering

Context:

  • Dry eye disease (DED) is a prevalent condition with rising incidence.
  • Elevated tear osmolarity is a significant contributor to DED symptoms, ocular surface damage, and inflammation.

Purpose:

  • To review the advancements in tear osmolarity research.
  • To discuss the diagnostic and therapeutic applications of tear osmolarity in dry eye management.
  • To explore the future clinical potential of hypotonic artificial tears.

Summary:

  • Tear osmolarity measurement has advanced, leading to increased research and reporting on its role in normal and dry eyes across diverse regions.
  • This review covers the progress in tear osmolarity research, establishes normal and abnormal ranges, and details its diagnostic and therapeutic utility in dry eye.
  • The potential clinical use of hypotonic artificial tears for managing dry eye is also examined.

Impact:

  • Highlights the importance of tear osmolarity as a biomarker for dry eye disease.
  • Informs clinicians about the latest diagnostic and therapeutic strategies for dry eye.
  • Suggests a promising avenue for future dry eye treatments with hypotonic artificial tears.