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Updated: May 31, 2026

An In Vitro Model for Measuring Immune Responses to Malaria in the Context of HIV Co-infection

An In Vitro Model for Measuring Immune Responses to Malaria in the Context of HIV Co-infection

Published on: October 6, 2015

Artemisinins and immune system.

Lubna Shakir¹, Muzammal Hussain, Aqeel Javeed

¹Department of Pharmacology & Toxicology, University of Veterinary and Animal Sciences, Lahore, Pakistan.

European Journal of Pharmacology

|July 16, 2011

Summary

This summary is machine-generated.

Artemisinins, crucial antimalarial drugs, exhibit significant immunomodulatory effects. They suppress immune cells and cytokine release, suggesting broader therapeutic potential beyond malaria treatment.

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Last Updated: May 31, 2026

An In Vitro Model for Measuring Immune Responses to Malaria in the Context of HIV Co-infection

An In Vitro Model for Measuring Immune Responses to Malaria in the Context of HIV Co-infection

Published on: October 6, 2015

Area of Science:

Immunology
Pharmacology
Infectious Diseases

Background:

Artemisinins are primary antimalarial drugs, often used in combination therapies.
Traditional antiprotozoal drugs can modulate the immune system.
Artemisinins possess known immunomodulatory properties requiring further investigation.

Purpose of the Study:

To review the immunomodulatory effects of artemisinins on various immune cells.
To explore the therapeutic potential of artemisinins in inflammation, autoimmunity, and delayed-type hypersensitivity.

Main Methods:

Literature review of data-based studies on artemisinins' immunomodulatory effects.
Analysis of artemisinins' impact on neutrophils, macrophages, splenocytes, T cells, and B cells.
Examination of artemisinins' role in regulating cellular proliferation and cytokine release.

Main Results:

Artemisinins demonstrate immunosuppressive traits on multiple immune components.
Regulation of cellular proliferation and cytokine release are key mechanisms.
Evidence suggests artemisinins influence neutrophils, macrophages, splenocytes, T cells, and B cells.

Conclusions:

Artemisinins possess significant immunomodulatory activities beyond their antimalarial function.
These immunomodulatory effects highlight potential therapeutic applications in inflammatory and autoimmune conditions.
Further research into artemisinins' immune-modulating mechanisms is warranted for novel therapeutic strategies.