Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypothalamic-pituitary-adrenal function in extrinsic asthma.

D W Morrish, B J Sproule, T H Aaron

    Chest
    |February 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Diagnosis and treatment of osteoporosis before and after admission to long-term care institutions.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2011
    Same author

    Oral bisphosphonates are associated with reduced mortality after hip fracture.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2010
    Same author

    Cost-effectiveness of a multifaceted intervention to improve quality of osteoporosis care after wrist fracture.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2010
    Same author

    Nurse case-manager vs multifaceted intervention to improve quality of osteoporosis care after wrist fracture: randomized controlled pilot study.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2010
    Same author

    Role of the inhalation therapist.

    Canadian Medical Association journal·2010
    Same author

    TREATMENT OF PERENNIAL ALLERGIC RHINITIS.

    Canadian Medical Association journal·2010
    Same journal

    The effect of a two-day stay at high altitude (2500 m) on right ventricular afterload and oxygen delivery in patients with pulmonary vascular disease A randomized controlled crossover trial.

    Chest·2026
    Same journal

    A Comparative Study of Radiation Exposure in Conventional and Robotic Bronchoscopy.

    Chest·2026
    Same journal

    Independent Prognostic Contributions of Anti-Ro52 and Anti-MDA5 in Autoimmune-Associated Interstitial Lung Disease.

    Chest·2026
    Same journal

    Lung aeration and gas exchange in SGA or AGA infants with moderate-severe BPD: secondary analysis of the PATH-BPD study.

    Chest·2026
    Same journal

    Lung Cancer Incidence and Mortality after Negative Low-Dose CT Screening Results.

    Chest·2026
    Same journal

    Symptom prevalence and impact on lung cancer risk in the SUMMIT study.

    Chest·2026
    See all related articles

    Hypothalamic-pituitary-adrenal (HPA) function is normal in patients with extrinsic asthma. Studies found no differences in hormone levels between asthmatics and controls, suggesting previous findings may be due to patient selection or methods.

    Area of Science:

    • Endocrinology
    • Pulmonology
    • Immunology

    Background:

    • Extrinsic asthma is a common condition with potential systemic effects.
    • Previous studies have suggested possible hypothalamic-pituitary-adrenal (HPA) axis dysfunction in asthma patients.
    • The HPA axis plays a crucial role in stress response and immune regulation.

    Purpose of the Study:

    • To investigate hypothalamic-pituitary-adrenal (HPA) axis function in patients with extrinsic asthma.
    • To determine if HPA axis function correlates with asthma severity or duration.
    • To clarify discrepancies in previous research regarding HPA function in asthma.

    Main Methods:

    • Assessed HPA function by measuring plasma adrenocorticotropic hormone (ACTH) and 11-deoxycortisol after metyrapone administration.

    Related Experiment Videos

  • Measured cortisol levels following cosyntropin stimulation.
  • Compared results between 25 extrinsic asthma patients and 20 age-matched healthy controls.
  • Correlated hormonal responses with pulmonary function tests in 23 asthmatic patients.

    • Main Results:

    • No significant differences in ACTH, 11-deoxycortisol, or cortisol levels were found between asthmatic patients and controls.
    • HPA axis responses did not correlate with asthma duration or severity.
    • Pulmonary function tests showed no correlation with HPA axis markers.

    Conclusions:

    • Hypothalamic-pituitary-adrenal (HPA) axis function is not abnormal in patients with extrinsic asthma.
    • Previous reports of HPA dysfunction may stem from heterogeneous patient groups, methodological variations, or normal response variability.
    • This study supports the normality of HPA axis function in well-defined extrinsic asthma cohorts.