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Updated: May 31, 2026

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
Published on: January 31, 2022
Hepatic dysfunction
1Small Animal Internal Medicine, Department of Clinical Sciences, James L. Voss Veterinary Teaching Hospital, Colorado State University, 300 West Drake Road, Fort Collins, CO 80523, USA. vetmedguy@yahoo.com
Abstract:
This article reviews the common pathophysiology that constitutes hepatic dysfunction, regardless of the inciting cause. The systemic consequences of liver failure and the impact of this condition on other organ systems are highlighted. The diagnostic tests available for determining the cause and extent of liver dysfunction are outlined, treatment strategies aimed at supporting hepatic health and recovery are discussed, and prognosis is briefly covered. The article emphasizes the fact that because of the central role of the liver in maintaining normal systemic homeostasis, hepatic dysfunction cannot be effectively addressed as an isolated entity.
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