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Constructing Mutants in Serotype 1 Streptococcus pneumoniae strain 519/43

Constructing Mutants in Serotype 1 Streptococcus pneumoniae strain 519/43

Published on: September 11, 2020

Streptococcus equi: a pathogen restricted to one host.

Andrew S Waller¹, Romain Paillot¹, John F Timoney²

¹Centre for Preventive Medicine, Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk CB8 7UU, UK.

Journal of Medical Microbiology

|July 16, 2011

Summary

This summary is machine-generated.

Streptococcus equi subspecies equi causes strangles in horses, persisting in guttural pouches and spreading to other animals. Genetic changes in S. equi likely enhanced its ability to evade immune responses and multiply, leading to its emergence as a pathogen.

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Constructing Mutants in Serotype 1 Streptococcus pneumoniae strain 519/43

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Published on: September 11, 2020

Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing

Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing

Published on: December 23, 2022

Area of Science:

Veterinary Microbiology
Equine Infectious Diseases
Bacterial Pathogenesis

Background:

Strangles, caused by Streptococcus equi subspecies equi (S. equi), is a significant global equine infectious disease.
S. equi establishes persistent infections in the guttural pouches of recovered horses, facilitating onward transmission.
Understanding the evolution of S. equi is crucial for controlling strangles outbreaks.

Purpose of the Study:

To review the genetic events in S. equi evolution from Streptococcus equi subspecies zooepidemicus.
To explore how these genetic changes contribute to immune evasion and rapid multiplication.
To discuss the role of these events in the emergence of S. equi as a host-restricted pathogen.

Main Methods:

Review of recent research on S. equi genome.
Analysis of evolutionary pathways from S. equi subspecies zooepidemicus.
Discussion of genetic adaptations related to host-pathogen interactions.

Main Results:

Identification of key genetic events during S. equi evolution.
Evidence suggesting these events enhance immune evasion.
Link between genetic changes and pathogen's ability to multiply in tonsillar/lymphoid tissues.

Conclusions:

Specific genetic adaptations facilitated S. equi's evolution into a successful equine pathogen.
These adaptations are critical for its persistence and transmission.
Further research into these genetic events can inform strangles prevention and control strategies.