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Related Experiment Video

Updated: May 31, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Plasmablastic lymphoma and related disorders.

Eric D Hsi¹, Robert B Lorsbach, Falko Fend

¹Dept of Clinical Pathology, Cleveland Clinic, Cleveland, OH 44195, USA.

American Journal of Clinical Pathology

|July 16, 2011

Summary

This study reviews plasmablastic lymphomas (PBLs) and related disorders, focusing on distinct entities within this heterogeneous group. It provides diagnostic recommendations for these challenging B-cell lymphomas.

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Area of Science:

Hematopathology
Oncology
Immunophenotyping

Background:

B-cell lymphomas with plasmablastic features represent a heterogeneous group with overlapping characteristics.
Distinct clinicopathologic and molecular genetic features aid in recognizing specific entities.
The 2009 Society for Hematopathology/European Association for Haematopathology Workshop focused on plasmablastic lymphomas (PBLs) and related disorders.

Purpose of the Study:

To review plasmablastic lymphomas (PBLs) and related disorders based on submitted cases.
To illustrate key diagnostic points and highlight controversial areas in PBL classification.
To provide recommendations on assessment features and terminology for PBLs.

Main Methods:

Review of submitted cases from the 2009 Society for Hematopathology/European Association for Haematopathology Workshop.
Discussion of topics including human herpesvirus 8-associated Castleman disease, PBLs in HIV infection, and ALK+ DLBCL.
Analysis of lymphomas with plasmablastic or plasmacytic features.

Main Results:

Identification of distinct clinicopathologic and molecular genetic features for specific entities.
Clarification of diagnostic challenges and controversial aspects in PBLs.
Case-based illustrations of key diagnostic points.

Conclusions:

Recommendations for assessing features and standardized terminology in PBLs.
Improved understanding of the heterogeneity within B-cell lymphomas with plasmablastic features.
Guidance for pathologists dealing with PBLs and related entities.