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Updated: May 31, 2026

Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
Published on: November 14, 2017
Paraoxonase gene polymorphism and the risk for Alzheimer's disease in the polish population
A Klimkowicz-Mrowiec1, M Marona, P Wolkow
1Department of Neurology, School of Medicine, Jagiellonian University, ul. Botaniczna 3, Cracow, Poland. Aleksandra.Klimkowicz@mp.pl
Background:
The relationship between different paraoxonase (PON) gene polymorphisms and the risk of Alzheimer's disease (AD) was studied several times and the results were controversial.
Methods:
We investigated the association of 4 single-nucleotide polymorphisms (SNPs) of the PON1 (M55L; Q192R; -161C/T) and the PON2 (C311S) genes that were shown to affect the risk of sporadic AD. We studied 360 Caucasian cases with late-onset AD and 354 nondemented controls.
Results:
No significant differences were observed between the studied PON SNPs and AD risk. The results did not change after stratification of the apolipoprotein E status. Meta-analyses of studies in Caucasians assessing the associations between the PON1 M55L, -161C/T and Q192R SNPs and the risk of AD were performed, and no associations were found.
Conclusion:
Our results suggest that the studied PON1 and PON2 polymorphisms are not associated with late-onset AD.
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