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Updated: May 31, 2026

Identification of Post-translational Modifications of Plant Protein Complexes
Published on: February 22, 2014
The role of NDR1 in pathogen perception and plant defense signaling
Caleb Knepper1, Elizabeth A Savory, Brad Day
1Department of Energy, Plant Research Laboratory, Michigan State University, East Lansing, MI, USA.
Abstract:
The biochemical and cellular function of NDR1 in plant immunity and defense signaling has long remained elusive. Herein, we describe a novel role for NDR1 in both pathogen perception and plant defense signaling, elucidated by exploring a broader, physiological role for NDR1 in general stress responses and cell wall adhesion. Based on our predictive homology modeling, coupled with a structure-function approach, we found that NDR1 shares a striking similarity to mammalian integrins, well-characterized for their role in mediating the interaction between the extracellular matrix and stress signaling. ndr1-1 mutant plants exhibit higher electrolyte leakage following pathogen infection, compared to wild type Col-0. In addition, we observed an altered plasmolysis phenotype, supporting a role for NDR1 in maintaining cell wall-plasma membrane adhesions through mediating fluid loss under stress.
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