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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Computational Analysis

Background:

  • Retinopathy of prematurity (ROP) requires regular imaging for monitoring.
  • Handheld retinal cameras can inadvertently cause pressure artifacts during imaging.
  • Quantifying these artifacts is essential for diagnostic accuracy.

Purpose of the Study:

  • To quantify retinal vascular changes caused by camera pressure during ROP imaging.
  • To compare vascular parameters between images with and without compression artifacts.
  • To assess the impact of pressure on retinal vessel diameter, curvature, and tortuosity.

Main Methods:

  • Analysis of wide-angle retinal photographs from routine ROP examinations.
  • Matching vascular trees in images with and without compression artifacts.
  • Utilizing Retinal Image multiScale Analysis (RIMA) software for quantitative assessment.
  • Statistical analysis using a two-level linear model for integrated curvature (IC), diameter (d), and tortuosity index (TI).

Main Results:

  • Significant reduction in arteriolar and venular diameter (d) in images with compression artifacts (P<0.01).
  • Significant decrease in arterial integrated curvature (IC) in compressed images (P<0.05).
  • No significant changes in vascular tortuosity index (TI) were observed between groups.

Conclusions:

  • Non-intentional corneal pressure from the RetCam lens can compress and alter retinal vessel diameter.
  • Severe pressure may lead to the collapse of retinal vessels.
  • Avoiding compression artifacts, indicated by the absence of the arterial blood column at the optic nerve head, is critical for accurate ROP imaging.