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Related Concept Videos

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Stroke: Introduction and Types01:29

Stroke: Introduction and Types

A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...

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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

A spontaneous decrease of blood pressure occurs in acute ischemic stroke with favourable neurological course.

P Rossi1, C Mandelli, D Manganaro

  • 1Department of Emergency Medicine, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milano, Itlay.

The Open Neurology Journal
|July 16, 2011
PubMed
Summary
This summary is machine-generated.

Blood pressure (BP) in acute ischemic stroke does not predict stroke severity or early outcomes. Patients experiencing neurological improvement show a reduction in BP profiles, suggesting a dynamic relationship.

Keywords:
Acute ischemic strokeblood pressure.

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Area of Science:

  • Neurology
  • Cardiology
  • Clinical Research

Background:

  • The relationship between blood pressure (BP) and clinical outcomes in acute ischemic stroke is not well-defined.
  • Understanding this association is crucial for managing stroke patients effectively.

Purpose of the Study:

  • To investigate the association between BP measurements and stroke severity in the acute phase.
  • To determine if early changes in neurological status influence BP profiles.
  • To explore the predictive value of admission BP for early neurological improvement.

Main Methods:

  • 57 patients with acute ischemic stroke were enrolled.
  • Blood pressure (BP) was measured using a standard sphygmomanometer on admission and 24-hour ambulatory BP monitoring (ABPM) on days 1 and 6.
  • Patients were categorized by neurological deficit severity (NIHSS score) and early neurological improvement (≥4-point NIHSS reduction by day 6).

Main Results:

  • Admission sphygmomanometric systolic BP was higher in mild/moderate stroke (NIHSS ≤ 10) compared to moderate/severe (NIHSS > 10), but ABPM showed no difference.
  • No significant differences in admission BP or ABPM were found between groups with and without early neurological improvement.
  • Clinically improved patients (group C) exhibited a significant reduction in systolic BP from day 1 to day 6 (p < 0.05) compared to non-improved patients (group D).

Conclusions:

  • Admission blood pressure does not correlate with stroke severity or predict early neurological outcomes.
  • Patients demonstrating early neurological improvement experience a concurrent reduction in their BP profile.
  • These findings highlight a dynamic interplay between neurological recovery and BP regulation post-stroke.