Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Aneurysm I: Introduction01:30

Aneurysm I: Introduction

An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
Aneurysm IV: Nursing Management01:22

Aneurysm IV: Nursing Management

Vigilant monitoring for aneurysm rupture is essential for patients undergoing aortic surgery.Preoperative Nursing ManagementContinuously monitor the patient for manifestations of aneurysm rupture, such as pallor, weakness, tachycardia, hypotension, abdominal, back, groin, or periumbilical pain, changes in consciousness, and a pulsating abdominal mass. Regularly assess the patient's peripheral pulses.Instruct the patient to consume a clear liquid diet the day before surgery and administer...
Epistaxis01:30

Epistaxis

Epistaxis, or nosebleeds, occurs when small, swollen blood vessels in the nasal mucous membrane rupture. Typically, the anterior septum is the primary site of occurrence.
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dynamic Intracranial Pressure Waveform Morphology Predicts Ventriculitis.

Neurocritical care·2021
Same author

Early Postmarket Results with EmboTrap II Stent Retriever for Mechanical Thrombectomy: A Multicenter Experience.

AJNR. American journal of neuroradiology·2021
Same author

Erratum to: Training guidelines for endovascular stroke intervention: an international multi-society consensus document.

Neuroradiology·2017
Same author

Training Guidelines for Endovascular Stroke Intervention: An International Multi-Society Consensus Document.

Interventional neurology·2016
Same author

Training guidelines for endovascular stroke intervention: an international multi-society consensus document.

Neuroradiology·2016
Same author

Training Guidelines for Endovascular Ischemic Stroke Intervention: An International Multi-Society Consensus Document.

AJNR. American journal of neuroradiology·2016
Same journal

Mental Health Outcomes After Neurocritical Care: A Systematic Review and Meta-analysis.

Neurocritical care·2026
Same journal

Neutrophil Extracellular Traps in Patients with Intracerebral Hemorrhage.

Neurocritical care·2026
Same journal

Revisiting the Role of Valproic Acid in Neurosurgical ICU Agitation.

Neurocritical care·2026
Same journal

Low-Dose Buprenorphine Initiations During Opioid and Sedative Weaning in Mechanically Ventilated Neurocritical Care Patients: A Retrospective Pilot Cohort Study.

Neurocritical care·2026
Same journal

A Sinus Arrhythmia that Reversed Cerebral Blood Flow in Pediatric Trauma.

Neurocritical care·2026
Same journal

Neurocritical Care Fellowship Training in the USA: Challenges and Potential Solutions.

Neurocritical care·2026
See all related articles

Related Experiment Video

Updated: May 31, 2026

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage
10:34

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage

Published on: August 30, 2020

Rebleeding after aneurysmal subarachnoid hemorrhage.

R M Starke1, E S Connolly,

  • 1Department of Neurosurgery, University of Virginia School of Medicine, Charlottesville, VA, USA.

Neurocritical Care
|July 16, 2011
PubMed
Summary
This summary is machine-generated.

Ultra-early rebleeding after aneurysmal subarachnoid hemorrhage (SAH) may occur in up to 17% of patients, significantly impacting outcomes. Antifibrinolytic therapy shows limited overall benefit for reducing rebleeding risk.

More Related Videos

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
09:14

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model

Published on: June 18, 2021

A Murine Model of Subarachnoid Hemorrhage
07:40

A Murine Model of Subarachnoid Hemorrhage

Published on: November 21, 2013

Related Experiment Videos

Last Updated: May 31, 2026

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage
10:34

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage

Published on: August 30, 2020

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
09:14

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model

Published on: June 18, 2021

A Murine Model of Subarachnoid Hemorrhage
07:40

A Murine Model of Subarachnoid Hemorrhage

Published on: November 21, 2013

Area of Science:

  • Neurosurgery
  • Neurology
  • Critical Care Medicine

Background:

  • Rebleeding after aneurysmal subarachnoid hemorrhage (SAH) significantly worsens patient outcomes.
  • Previous studies may have underestimated rebleeding rates by not capturing ultra-early events.
  • Understanding rebleeding incidence is crucial for optimizing patient management.

Purpose of the Study:

  • To review the incidence and timing of rebleeding after aneurysmal SAH.
  • To evaluate the effectiveness of antifibrinolytic therapy in preventing rebleeding.
  • To identify potential strategies for reducing rebleeding risk.

Main Methods:

  • An electronic literature search was conducted for English-language articles from February 1975 to October 2010.
  • 43 articles (40 original research, 3 reviews) focusing on human aneurysmal SAH rebleeding were selected.
  • Data on rebleeding incidence, timing, and treatment effects were analyzed.

Main Results:

  • While many studies reported rebleeding rates of approximately 4%, investigations into ultra-early rebleeding showed incidences of 9-17% within 24 hours.
  • The majority of ultra-early rebleeds occurred within 6 hours of the initial SAH.
  • Antifibrinolytic therapy has not demonstrated clear overall therapeutic benefit in reducing rebleeding.

Conclusions:

  • Ultra-early rebleeding is a significant concern after aneurysmal SAH, potentially occurring more frequently than previously recognized.
  • Short-course antifibrinolytic therapy might be beneficial before aneurysm repair, but further data are needed.
  • Current evidence does not support the routine use of antifibrinolytics to prevent rebleeding after SAH.