Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 31, 2026

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma
09:17

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma

Published on: September 13, 2022

Macromolecule content influences proton diffusibility in gliomas.

Einar Goebell1, Jens Fiehler, Susanne Siemonsen

  • 1Department of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf (UKE), Martinistraße 52, 20246 Hamburg, Germany. e.goebell@uke.de

European Radiology
|July 16, 2011
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical evidence standards for high-risk endovascular devices in ischemic stroke: a European multisociety consensus.

Journal of neurointerventional surgery·2026
Same author

The position of the mental foramen on panoramic radiographs of patients with neurofibromatosis type 1.

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery·2026
Same author

Endovascular treatment for medium or distal vessel occlusion stroke (DISTAL): 12-month outcomes of a multicentre, open-label, randomised trial.

The Lancet. Neurology·2026
Same author

Combined Soft and Hard Tissue Facial Lesions In Early Childhood Pioneering the Diagnosis of the Tumor Predisposition Syndrome Neurofibromatosis Type 1.

Cancer diagnosis & prognosis·2026
Same author

Processing pipeline for large optical coherence elastography datasets with quasi-static air-jet excitation: application to human brain tumor tissue.

Biomedical optics express·2026
Same author

The HIT Network for Children and Adolescents With CNS Tumors Facilitates Improvements of Diagnostic Assessments, Multimodal Treatments, Individual Counseling, and Research in Germany, Austria, and Switzerland.

Pediatric blood & cancer·2026

Macromolecules influence proton diffusion in brain tumors, alongside mechanical barriers. This finding aids understanding of glioma diffusion phenomena and extracellular matrix composition.

Area of Science:

  • Neuro-oncology
  • Biophysics
  • Medical Imaging

Background:

  • Extracellular matrix composition, particularly hydrophilic components like proteins, can significantly impact diffusion in gliomas.
  • Understanding these diffusion phenomena is crucial for diagnosing and characterizing brain tumors.

Purpose of the Study:

  • To investigate the relationship between extracellular matrix properties and diffusion characteristics in non-necrotic gliomas.
  • To determine if macromolecular content influences proton diffusivity in brain tumors.

Main Methods:

  • Preoperative MRI scans including Magnetization Transfer (MTR), Triple Echo T2-weighted (T2W), and Diffusion Weighted Imaging (DWI) were performed on 24 glioma patients.
  • Apparent Diffusion Coefficient (ADC), quantitative T2, and MTR maps were calculated, with regions of interest placed in tumor centers and contralateral hemispheres.

More Related Videos

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
05:45

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

Published on: July 31, 2017

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
12:52

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

Related Experiment Videos

Last Updated: May 31, 2026

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma
09:17

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma

Published on: September 13, 2022

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
05:45

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

Published on: July 31, 2017

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
12:52

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

  • Statistical analysis was used to correlate imaging parameters.

    • Main Results:

    • Significant differences were observed in ADC, T2, and MTR values between tumor centers and normal brain tissue.
    • Mean ADC, T2, and MTR values showed significant correlations with each other (p < 0.01).
    • Tumor tissue exhibited higher ADC and T2 values and lower MTR values compared to normal brain tissue.

    Conclusions:

    • Macromolecules binding protons are a key factor determining proton diffusivity in brain tumors.
    • Other factors like mechanical barriers and extracellular space size also play a role in glioma diffusion.
    • These findings enhance the understanding of biophysical properties influencing diffusion in brain tumors.