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Adiponectin receptor expression in human malignant tissues.

Sharon H Chou1, Sofia Tseleni-Balafouta, Hyun-Seuk Moon

  • 1Division of Endocrinology, Diabetes, & Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 002215, USA.

Hormones & Cancer
|July 16, 2011
PubMed
Summary
This summary is machine-generated.

Adiponectin receptors AdipoR1 and AdipoR2 are expressed in various cancers. AdipoR1 is more common in obesity-associated cancers, suggesting a role in cancer development.

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Published on: July 17, 2018

Area of Science:

  • Oncology
  • Endocrinology
  • Molecular Biology

Background:

  • Adiponectin is implicated in obesity-related cancers and possesses antineoplastic properties.
  • Adiponectin exerts its effects through AdipoR1 and AdipoR2 receptors.
  • Previous studies have not extensively investigated AdipoR1 and AdipoR2 expression across diverse cancer types.

Purpose of the Study:

  • To investigate the expression patterns of AdipoR1 and AdipoR2 in a range of human cancers.
  • To compare AdipoR1 and AdipoR2 expression in malignant versus adjacent non-malignant tissues.
  • To explore the correlation between adiponectin receptor expression and obesity association in cancers.

Main Methods:

  • Immunohistochemistry was used to assess AdipoR1 and AdipoR2 expression in archival specimens of renal cell carcinoma, hepatocellular carcinoma, melanoma, cholangiocarcinoma, bladder transitional cell carcinoma, ovarian epithelial carcinoma, cervical squamous cell carcinoma, and adrenocortical carcinoma.
  • Real-time polymerase chain reaction analyzed mRNA expression of adiponectin receptors in renal cell carcinoma.
  • Western blotting confirmed receptor presence and investigated adiponectin-mediated signaling pathways in the 786-O renal cancer cell line.

Main Results:

  • AdipoR1 expression was significantly more prevalent in obesity-associated cancers compared to non-obesity-associated cancers.
  • Renal cell carcinoma, a cancer strongly linked to obesity, showed high AdipoR1 expression (93.8%) compared to cervical squamous cell carcinoma (44.9%).
  • No significant differences in AdipoR1/AdipoR2 expression or mRNA levels were found between malignant and benign kidney tissues, nor were correlations observed with tumor prognostic factors.

Conclusions:

  • This study provides the first report on AdipoR1 and AdipoR2 expression in several previously unstudied cancer types.
  • AdipoR1 demonstrates a more ubiquitous expression in obesity-associated malignancies.
  • Adiponectin signaling pathways are active in renal cancer cells, warranting further investigation into their therapeutic potential.