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Updated: May 31, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Androgen action in prostate cancer

Sujit Basu1, Donald J Tindall

  • 1Department of Pathology, Ohio State University, Columbus, OH 43210, USA.

Hormones & Cancer
|July 16, 2011
PubMed

Insights

Androgens fuel prostate cancer growth by binding to the androgen receptor (AR). Androgen ablation is a key therapy for advanced prostate cancer, targeting this dependency.

Area of Science:

  • Oncology
  • Endocrinology
  • Molecular Biology

Background:

  • Prostate cancer is a significant global health concern for men.
  • Androgens are essential for normal prostate function and growth.
  • The androgen receptor (AR) mediates androgen action in prostate tissues.

Purpose of the Study:

  • To review the critical role of androgens in prostate cancer development and progression.
  • To summarize current therapeutic strategies targeting androgen signaling.

Main Methods:

  • Literature review of existing research on androgens and prostate cancer.
  • Analysis of the androgen receptor's function in prostate tumor biology.

Main Results:

  • Androgens are indispensable for prostate cancer cell growth and survival.
  • Most prostate tumors exhibit continued dependence on androgens.
  • Androgen deprivation therapy is a primary treatment for advanced prostate cancer.

Conclusions:

  • Understanding androgen-AR interactions is crucial for prostate cancer management.
  • Targeting androgen signaling remains a cornerstone of advanced prostate cancer therapy.

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