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Related Experiment Video

Updated: May 31, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Androgen action in prostate cancer.

Sujit Basu¹, Donald J Tindall

¹Department of Pathology, Ohio State University, Columbus, OH 43210, USA.

Hormones & Cancer

|July 16, 2011

Summary

Androgens fuel prostate cancer growth by binding to the androgen receptor (AR). Androgen ablation is a key therapy for advanced prostate cancer, targeting this dependency.

Area of Science:

Oncology
Endocrinology
Molecular Biology

Background:

Prostate cancer is a significant global health concern for men.
Androgens are essential for normal prostate function and growth.
The androgen receptor (AR) mediates androgen action in prostate tissues.

Purpose of the Study:

To review the critical role of androgens in prostate cancer development and progression.
To summarize current therapeutic strategies targeting androgen signaling.

Main Methods:

Literature review of existing research on androgens and prostate cancer.
Analysis of the androgen receptor's function in prostate tumor biology.

Main Results:

Androgens are indispensable for prostate cancer cell growth and survival.

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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

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Published on: March 6, 2018

Murine Prostate Micro-dissection and Surgical Castration

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Published on: May 11, 2016

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 18, 2013

Most prostate tumors exhibit continued dependence on androgens.

Androgen deprivation therapy is a primary treatment for advanced prostate cancer.

Conclusions:

Understanding androgen-AR interactions is crucial for prostate cancer management.
Targeting androgen signaling remains a cornerstone of advanced prostate cancer therapy.