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Primer and interviews: promises and realities of induced pluripotent stem cells

Julie C Kiefer1

  • 1Department of Neurobiology and Anatomy, 401 MREB, University of Utah, Salt Lake City, Utah 84132, USA. jkiefer@neuro.utah.edu

Developmental Dynamics : an Official Publication of the American Association of Anatomists
|July 16, 2011
PubMed

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
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Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
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