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Updated: May 31, 2026

Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers
Published on: September 19, 2017
Kinetic and thermodynamic control of G-quadruplex folding
Yong Xue1, Jia-quan Liu, Ke-wei Zheng
1State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Abstract:
A matter of speed: when allowed to fold in a K(+)/poly(ethylene glycol) solution, the guanine (G)-rich strand of vertebrate telomere DNA forms a parallel/antiparallel G-quadruplex, which is a (3+1) hybrid, within microseconds before slowly transforming into the parallel one within hours. Thus, the conformation that a G-quadruplex initially adopts under physiological conditions may not be the one it adopts at the equilibrium state.
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