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A structural protein encoded by the 5' region of the hepatitis C virus genome efficiently detects viral infection
N Kato1, M Hijikata, Y Ootsuyama
1Virology Division, National Cancer Center Research Institute, Tokyo.
Japanese Journal of Cancer Research : Gann
|November 1, 1990
Abstract:
A structural region of the hepatitis C virus genome was molecularly cloned. A protein expressed in vitro by transcription followed by translation was precipitated immunologically by sera from patients with chronic hepatitis or hepatocellular carcinoma that were positive for antibody against the non-structural protein, C100, of hepatitis C virus, but not by sera from healthy persons. Thus, this structural protein should be useful for detection of infection with this virus.