Related Experiment Video
Updated: May 31, 2026

Studying Wnt Signaling During Patterning of Conducting Airways
Published on: October 16, 2016
Impact of WNT signaling on tissue lineage differentiation in the early mouse embryo
Satomi S Tanaka1, Yoji Kojima, Yasuka L Yamaguchi
1Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan. stanaka@kumamoto-u.ac.jp;
Abstract:
WNT signaling activity is involved in the regulation of many cellular functions, including proliferation, migration, cell fate specification, maintenance of pluripotency and induction of tumorigenicity. Here we summarize recent progress towards understanding the regulation of canonical WNT/β-catenin signaling activity through feedback regulatory loops involving the ligands, agonists and antagonists, the availability of intracellular pools of active β-catenin and the cross-regulation of the WNT activity by β-catenin independent pathway. We also review recent findings on the role of WNT/β-catenin signaling in tissue lineage differentiation during embryogenesis and the maintenance and self renewal of embryo-derived stem cells in vitro.
More Related Videos
07:34The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions
Published on: February 16, 2017
11:25Quantitative Analysis of Protein Expression to Study Lineage Specification in Mouse Preimplantation Embryos
Published on: February 22, 2016
Related Concept Videos
Non-Canonical Wnt Signaling Pathways
Non-Canonical Wnt Signaling Pathways
Canonical Wnt Signaling Pathway
Canonical Wnt Signaling Pathway
Determination
Gastrulation