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Updated: May 31, 2026

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
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Published on: February 6, 2019

Adolescent binge drinking linked to abnormal spatial working memory brain activation: differential gender effects.

Lindsay M Squeglia1, Alecia Dager Schweinsburg, Carmen Pulido

  • 1Joint Doctoral Program in Clinical Psychology, San Diego State University/University of California San Diego, San Diego, California, USA.

Alcoholism, Clinical and Experimental Research
|July 19, 2011
PubMed
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Adolescent binge drinking impacts spatial working memory (SWM) differently in males and females. Female binge drinkers showed reduced brain activation and poorer cognitive performance, suggesting greater vulnerability to alcohol

Area of Science:

  • Neuroscience
  • Adolescent Development
  • Neuroimaging

Background:

  • Binge drinking is common in adolescents and raises concerns about neurocognitive development.
  • Heavy substance use, including binge drinking, is linked to cognitive deficits, especially in spatial working memory (SWM).
  • Understanding gender-specific effects of binge drinking on SWM is crucial for identifying early consequences on adolescent brain function.

Purpose of the Study:

  • To investigate the gender-specific effects of adolescent binge drinking on spatial working memory (SWM) brain activation.
  • To determine the relationship between SWM brain activation patterns and cognitive performance in adolescent binge drinkers.
  • To explore potential gender differences in vulnerability to alcohol's neurotoxic effects during adolescence.

Main Methods:

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  • Recruited 40 adolescent binge drinkers and 55 controls (ages 16-19).
  • Administered neuropsychological tests, substance use interviews, and a spatial working memory (SWM) task during functional magnetic resonance imaging (fMRI).
  • Analyzed brain activation in response to the SWM task, focusing on gender-specific differences and correlations with cognitive performance.

Main Results:

  • Significant interactions between binge drinking status and gender were observed in multiple brain regions (frontal, anterior cingulate, temporal, cerebellar).
  • Female binge drinkers exhibited reduced SWM activation compared to controls, associated with poorer attention and memory.
  • Male binge drinkers showed increased SWM activation compared to controls, linked to better spatial performance.

Conclusions:

  • Adolescent binge drinking is associated with gender-specific alterations in brain activation during SWM tasks, impacting cognitive performance.
  • Females may be more susceptible to alcohol's neurotoxic effects, while males might show more resilience.
  • SWM brain activation may serve as an early neurocognitive marker for alcohol's impact on adolescent brain function and future behaviors.