Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Leishmaniasis01:30

Leishmaniasis

Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Tuberculosis01:23

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Non-typhoidal Salmonella co-infect and complicate Plasmodium falciparum malaria in children under-five: A prospective cohort study on clinical presentation and outcome in Kisantu district hospital, DR Congo.

PLoS neglected tropical diseases·2026
Same author

Urgent call for an Ebola truce in DR Congo.

Lancet (London, England)·2026
Same author

Corrigendum to 'Efficacy of susceptibility-matched antibiotic treatment of nontyphoidal Salmonella bloodstream infections: a prospective observational study in hospitalized children under 5 in the Democratic of Congo.' Clin Microbiol Infect. 32 (2026) 593-602.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2026
Same author

Differentiating Spotted Fever From Scrub Typhus Based on Clinical and Laboratory Features: A Retrospective Cohort Study From South India.

Open forum infectious diseases·2026
Same author

Using oral and parenteral formulation of AWaRe antibiotics as a proxy estimate of community and hospital healthcare sector use.

JAC-antimicrobial resistance·2026
Same author

Simple clinical decision model for predicting leptospirosis: a secondary analysis of a randomized controlled trial.

Transactions of the Royal Society of Tropical Medicine and Hygiene·2026

Related Experiment Video

Updated: May 31, 2026

Simplified Whole Body Plethysmography to Characterize Lung Function During Respiratory Melioidosis
07:27

Simplified Whole Body Plethysmography to Characterize Lung Function During Respiratory Melioidosis

Published on: February 24, 2023

Melioidosis, phnom penh, Cambodia.

Erika Vlieghe1, Lim Kruy, Birgit De Smet

  • 1Institute of Tropical Medicine, Antwerp, Belgium. evlieghe@itg.be

Emerging Infectious Diseases
|July 19, 2011
PubMed
Summary

Melioidosis is a serious bacterial infection in Cambodia, often linked to diabetes and the rainy season. Inappropriate treatment significantly increases the high fatality rate in patients with bloodstream infections.

More Related Videos

Total Protein Extraction and 2-D Gel Electrophoresis Methods for Burkholderia Species
08:31

Total Protein Extraction and 2-D Gel Electrophoresis Methods for Burkholderia Species

Published on: October 15, 2013

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs
11:36

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Published on: April 21, 2012

Related Experiment Videos

Last Updated: May 31, 2026

Simplified Whole Body Plethysmography to Characterize Lung Function During Respiratory Melioidosis
07:27

Simplified Whole Body Plethysmography to Characterize Lung Function During Respiratory Melioidosis

Published on: February 24, 2023

Total Protein Extraction and 2-D Gel Electrophoresis Methods for Burkholderia Species
08:31

Total Protein Extraction and 2-D Gel Electrophoresis Methods for Burkholderia Species

Published on: October 15, 2013

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs
11:36

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Published on: April 21, 2012

Area of Science:

  • Infectious Diseases
  • Tropical Medicine
  • Public Health

Background:

  • Melioidosis is a significant cause of morbidity and mortality in tropical regions.
  • Understanding risk factors and outcomes is crucial for effective public health strategies.

Purpose of the Study:

  • To describe the clinical characteristics, risk factors, and outcomes of adult melioidosis patients in Cambodia.
  • To analyze the impact of the rainy season and diabetes on melioidosis incidence.
  • To evaluate the case-fatality rate and identify factors associated with mortality.

Main Methods:

  • Retrospective case series of 58 adult patients diagnosed with melioidosis between 2007 and 2010 in Cambodia.
  • Data collection included patient demographics, clinical presentation, risk factors (e.g., diabetes), season of infection, and treatment outcomes.
  • Analysis of bloodstream infection prevalence and case-fatality rates.

Main Results:

  • Diabetes was identified as the primary risk factor in 59% of cases.
  • A majority of infections (67%) occurred during the rainy season.
  • Bloodstream infection was prevalent in 67% of patients, constituting 12% of all bloodstream infections.
  • The overall case-fatality rate was high at 52%.

Conclusions:

  • Melioidosis poses a substantial public health challenge in Cambodia, particularly for diabetic individuals during the rainy season.
  • The high case-fatality rate underscores the need for timely and appropriate empiric treatment.
  • Further research into optimal treatment protocols and preventative measures is warranted.