Stress impairs consolidation of recognition memory after blocking drug memory reconsolidation

When a consolidated memory is retrieved, it returns to a vulnerable state. To persist it must undergo another process, called memory reconsolidation. It has been demonstrated that disrupting the reconsolidation of a drug-specific memory is a powerful method for intervention in drug addiction. More specifically, previous studies suggested that certain types of stress can successfully disrupt reconsolidation of drug memories. While it is typically used for a single purpose, stress contributes to a myriad of different memory paradigms and processes. These additional effects of stress on unrelated memory processes are often overlooked. In this study, cold water stress was used to assess its effects on drug memory. Rats were trained to acquire methamphetamine (MA) conditioned place preference (CPP) by confining rats to a MA-paired chamber for 10min. The new object recognition task (NOR) was given before and after stress-interrupting reconsolidation of MA-induced memory. Our data demonstrate that stress impairs the consolidation process of NOR memory when it is used to block drug memory reconsolidation, while stress exhibits no effect on acquiring a new memory, suggesting potential strategies of stress for therapeutic invention in drug addiction.