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Dynamics of preferential substrate recognition in HIV-1 protease: redefining the substrate envelope

Ayşegül Ozen1, Türkan Haliloğlu, Celia A Schiffer

  • 1Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

Journal of Molecular Biology
|July 19, 2011
PubMed
Summary

Drug resistance in HIV-1 protease (PR) limits antiviral therapy. A dynamic substrate envelope model improves understanding of how resistant HIV-1 PR variants recognize diverse substrates, aiding new drug design.

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