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Updated: May 31, 2026
09:05
MicroRNA-based Regulation of Picornavirus Tropism
Published on: February 6, 2017
Mechanistic intersections between picornavirus translation and RNA replication
1Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, California, USA.
Advances in Virus Research
|July 19, 2011
Summary
Picornaviruses like poliovirus use host factors for translation and replication. This review details how RNA elements and host factors manage the switch between translation and negative-strand RNA synthesis.
Area of Science:
- Virology
- Molecular Biology
- Biochemistry
Background:
- Picornaviridae are positive-strand RNA viruses utilizing internal ribosome entry sites (IRESs) for translation initiation.
- Viral replication occurs in the cytoplasm, requiring host cell factors for both translation and RNA synthesis.
Purpose of the Study:
- To review critical RNA elements and host factors involved in the poliovirus replication cycle.
- To provide an overview of the switch mechanism between IRES-dependent translation and negative-strand RNA synthesis.
Main Methods:
- Literature review focusing on poliovirus research.
- Analysis of critical RNA elements and host-dependent factors.
Main Results:
- Picornaviruses face a conflict between translation and negative-strand RNA synthesis due to opposing directions.
- The switch mechanism is crucial for coordinating these processes.
Conclusions:
- Understanding the interplay between RNA elements and host factors is key to poliovirus replication.
- The switch mechanism is central to the virus life cycle, balancing translation and replication needs.
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