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Related Experiment Video

Updated: May 31, 2026

Studying Food Reward and Motivation in Humans
12:09

Studying Food Reward and Motivation in Humans

Published on: March 19, 2014

Neural reward processing under dopamine agonists: imaging.

Jan Kassubek1, Birgit Abler, Elmar H Pinkhardt

  • 1Department of Neurology, University of Ulm, Ulm, Germany. jan.kassubek@uni-ulm.de

Journal of the Neurological Sciences
|July 19, 2011
PubMed
Summary
This summary is machine-generated.

Dopaminergic medications like levodopa and dopamine agonists (DA) can cause impulse control disorders (ICDs). Functional neuroimaging reveals altered brain reward pathways, particularly in the ventral striatum, linked to these medication side effects.

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Last Updated: May 31, 2026

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Published on: August 24, 2016

Area of Science:

  • Neuroscience
  • Pharmacology
  • Psychiatry

Background:

  • Impulse control disorders (ICDs) and punding are recognized side effects of dopaminergic medications (levodopa, dopamine agonists).
  • These conditions are part of dopamine dysregulation syndrome, characterized by reward seeking and addictive behaviors.
  • Understanding the neurobiology of reward processing is crucial for managing these side effects.

Purpose of the Study:

  • To investigate the functional brain changes associated with dopaminergic medication.
  • To explore the neurobiological underpinnings of impulse control disorders (ICDs) induced by dopaminergic therapy.
  • To review the application of functional neuroimaging in studying reward processing and medication effects.

Main Methods:

  • Utilized functional neuroimaging techniques, including functional magnetic resonance imaging (fMRI) and positron emission tomography (PET).
  • Conducted neuropsychological assessments to characterize brain functions related to reward processing.
  • Examined functional changes in brain networks involved in reward processing under dopaminergic medication.

Main Results:

  • Identified functional alterations in reward system networks, including striatal-thalamic loops, amygdala, and ventral tegmental area.
  • Observed altered ventral striatal functioning specifically linked to ICDs like pathological gambling.
  • Demonstrated a general sensitizing effect of dopamine agonist (DA) therapy toward ICDs.

Conclusions:

  • Functional neuroimaging provides insights into how dopaminergic medications alter reward processing.
  • Altered brain activity in reward pathways is associated with the development of ICDs.
  • Dopaminergic medication can induce a general susceptibility to impulse control disorders.