Software for semiparametric shared gamma and log-normal frailty models: An overview
Related Experiment Video
Updated: May 31, 2026

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach
Published on: July 3, 2020
Katharina Hirsch1, Andreas Wienke
1Martin-Luther-University Halle-Wittenberg, Institute of Medical Epidemiology, Biostatistics, and Informatics, Magdeburger Strasse 8, Halle (Saale), Germany. katharina.hirsch@medizin.uni-halle.de
Abstract:
In survival analysis individuals are followed over some period and the time until the transition from an initial to a final state is of particular interest. An important tool for analyzing potential risk factors of this transition is the Cox proportional hazards model. This model requires homogeneity in the study population and independence between the observations. An extension of the Cox model to deal with both, unobserved heterogeneity and clustered survival data, are frailty models [1]. Different software are available for the analysis of shared frailty models such as coxph, coxme, phmm, frailtyPenal, SPGAM or SPLN3. This makes it difficult for the user to find the appropriate tool for the specific problem under investigation. To compare the performance of the aforementioned software a large simulation study was conducted. Advantages and limitations of the software are discussed in detail.
Related Concept Videos
Parametric Survival Analysis: Weibull and Exponential Methods
Weibull Distribution
The Weibull distribution is a flexible model used in parametric survival analysis. It can handle both increasing and decreasing hazard rates, depending on its shape parameter...
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
Introduction To Survival Analysis
The primary goal of survival analysis is to estimate survival time—the time until a...
Statistical Methods for Analyzing Epidemiological Data
Assumptions of Survival Analysis
Biostatistics: Overview
Discrete variables are...
