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Updated: May 31, 2026

Rapid One-step Enzymatic Synthesis and All-aqueous Purification of Trehalose Analogues
Published on: February 17, 2017
Potential trehalase inhibitors: syntheses of trehazolin and its analogues
Ahmed El Nemr1, El Sayed H El Ashry
1Environmental Division, National Institute of Oceanography and Fisheries, Kayet Bey, El Anfoushy, Alexandria, Egypt.
Abstract:
Trehazolin is a natural pseudodisaccharide obtained from Micromonospora strain SANK 62390 and Amycolaptosis trehalostatica, and later on it was found to be widely distributed in microorganisms, insects, plants, and animals. It has received much attention because of its importance as an inhibitor of the enzyme trehalase. This article is focused on the synthesis of natural trehazolin and its analogues, with details of the synthetic methods. Sufficient information is given to permit the selection of a suitable synthetic route for trehazolin and/or its analogues. Various approaches are provided for the synthesis of natural trehazolin and its analogues in a way that enables the researcher to decide whether to use a certain procedure, modify it, or propose a new synthetic methodology.
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