Can a systems perspective help us appreciate the biological meaning of small effects?
Hana El-Samad1, Hiten D Madhani
1Department of Biochemistry and Biophysics, California Institute of Quantitative Biosciences, University of California-San Francisco, CA 94158, USA. helsamad@gmail.com
Abstract:
The study of dramatic phenotypes has been pivotal to elucidating biological mechanisms. Effectively approaching low-magnitude quantitative phenotypes, a common outcome of systematic loss-of-function studies, will be critical for understanding how individual components of cells interact to generate functioning systems.
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