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Updated: May 31, 2026

Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells
Published on: July 16, 2013
Extracellular movement of signaling molecules
Patrick Müller1, Alexander F Schier
1Department of Molecular and Cellular Biology, Harvard Stem Cell Institute, Broad Institute, Center for Brain Science, FAS Center for Systems Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA. pmueller@fas.harvard.edu
None:
Extracellular signaling molecules have crucial roles in development and homeostasis, and their incorrect deployment can lead to developmental defects and disease states. Signaling molecules are released from sending cells, travel to target cells, and act over length scales of several orders of magnitude, from morphogen-mediated patterning of small developmental fields to hormonal signaling throughout the organism. We discuss how signals are modified and assembled for transport, which routes they take to reach their targets, and how their range is affected by mobility and stability.
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