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Relationship between streaming potential and compressive stress in bovine intervertebral tissue
Kazuhiro Fujisaki1, Shigeru Tadano, Nozomu Asano
1Division of Human Mechanical Systems and Design, Faculty of Engineering, Hokkaido University, Kita-13, Nishi-8, Kita-ku, Sapporo 060-8628, Japan. fujiwax@eng.hokudai.ac.jp
Journal of Biomechanics
|July 19, 2011
Summary
Streaming potential in intervertebral discs, specifically the nucleus pulposus (NP) and annulus fibrosus (AF), linearly correlates with applied stress. This relationship is influenced by tissue type and compression rate but not AF anisotropy.
Area of Science:
- Biomaterials Science
- Biomechanics
- Tissue Engineering
Background:
- The intervertebral disc comprises nucleus pulposus (NP) and annulus fibrosus (AF), rich in negatively charged proteoglycans.
- Tissue deformation induces streaming potentials due to ion flow, contributing to the anisotropic properties of the AF.
Purpose of the Study:
- To investigate the relationship between streaming potential and applied stress in bovine intervertebral disc tissues.
- To analyze the influence of anisotropy and loading location on this relationship.
Main Methods:
- Columnar specimens (5.5 mm diameter, 3 mm thick) from AF, NP, and annulus-nucleus transition (AN) regions were prepared.
- Specimens were subjected to axial, circumferential, and radial loading to assess anisotropic properties.
- Streaming potential was measured under varying stress conditions, compression rates, and cyclic loading.
Main Results:
- Streaming potential exhibited a linear relationship with applied stress across all tested specimens.
- The linear coefficient (k(e)) varied with the tissue's extraction position but was independent of AF anisotropy.
- k(e) values were lower in AF compared to NP tissues and generally increased with faster compression rates (except in NP).
- Linear stress-streaming potential correlation persisted during cyclic loading, irrespective of tissue type or load frequency.
Conclusions:
- Streaming potential is a reliable indicator of applied stress in intervertebral disc tissues.
- Tissue composition (NP vs. AF) and compression dynamics significantly influence the streaming potential response.
- Findings provide insights into the electro-mechanical behavior of the intervertebral disc.
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