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Factors affecting epilepsy development and epilepsy prognosis in cerebral palsy
Gulen Gul Mert1, Faruk Incecik, Sakir Altunbasak
1Department of Pediatrics, Cukurova University, Adana, Turkey. dr_gulen@hotmail.com
Pediatric Neurology
|July 19, 2011
Summary
Neonatal seizures, family history of epilepsy, and mental retardation predict epilepsy development in cerebral palsy patients. Poor prognosis is linked to neonatal seizures and electroencephalography findings.
Area of Science:
- Neurology
- Pediatrics
- Epileptology
Background:
- Cerebral palsy (CP) is a common neurodevelopmental disorder.
- Epilepsy frequently co-occurs with cerebral palsy, impacting patient outcomes.
- Predicting epilepsy development and prognosis in CP is crucial for management.
Purpose of the Study:
- To identify factors predicting the presence of epilepsy in cerebral palsy patients.
- To determine predictors of epilepsy prognosis in individuals with cerebral palsy.
- To analyze the relationship between specific clinical and electrophysiological findings and epilepsy outcomes in CP.
Main Methods:
- A comparative study involving 42 patients with cerebral palsy (Group 1) and 56 patients with cerebral palsy and epilepsy (Group 2).
- Group 2 was categorized by epilepsy prognosis: good (seizure-free for 1 year) or poor.
- Logistic regression analysis was employed to identify independent predictors.
Main Results:
- Neonatal seizures, family history of epilepsy, and moderate to severe mental retardation were significantly higher in patients with epilepsy (Group 2).
- Univariate analysis identified neonatal seizures, electroencephalography (EEG) epileptic activity, and polytherapy as predictors of poor prognosis.
- Logistic regression revealed neonatal seizures and interictal epileptic activity on EEG as independent predictors of poor epilepsy outcome.
Conclusions:
- Neonatal seizures, family history of epilepsy, and mental retardation are significant predictors for developing epilepsy in cerebral palsy.
- Neonatal seizures and interictal epileptic activity on EEG are independent predictors of poor epilepsy prognosis in this population.
- Increasing age negatively impacts epilepsy treatment success in cerebral palsy patients.
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