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Updated: May 31, 2026

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy
11:27

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy

Published on: April 29, 2014

Vascular endothelial growth factor-targeted therapies in advanced renal cell carcinoma

Laurence Albiges1, Mohamed Salem, Brian Rini

  • 1Medical Oncology Department, Institut Gustave Roussy, 114 Rue Edouard Vaillant, Villejuif, France.

Hematology/Oncology Clinics of North America
|July 19, 2011
PubMed

Insights

Vascular endothelial growth factor (VEGF) drives renal cell carcinoma (RCC) progression. Therapies targeting the VEGF pathway have revolutionized metastatic RCC (mRCC) treatment and patient outcomes.

Area of Science:

  • Oncology
  • Nephrology
  • Molecular Biology

Background:

  • Vascular endothelial growth factor (VEGF) is crucial in renal cell carcinoma (RCC) pathogenesis.
  • VEGF pathway activation promotes angiogenesis, a hallmark of RCC tumor development.

Purpose of the Study:

  • To review the role of VEGF in RCC.
  • To discuss anti-VEGF therapies for metastatic RCC (mRCC).

Main Methods:

  • Literature review of studies on VEGF in RCC pathogenesis.
  • Analysis of approved and investigational anti-VEGF agents for mRCC.

Main Results:

  • Four anti-VEGF compounds (bevacizumab, sunitinib, sorafenib, pazopanib) are approved for mRCC.
  • Axitinib and tivozanib show promise in ongoing evaluations.

Conclusions:

  • Targeting the VEGF pathway has significantly improved mRCC management.
  • Ongoing research continues to advance treatment strategies for mRCC.

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