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Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
Zygotic Development And Stem Cell Formation01:10

Zygotic Development And Stem Cell Formation

The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...

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Related Experiment Video

Updated: May 31, 2026

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease
09:45

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease

Published on: April 12, 2021

[Lung development and mesenchymal stem cells].

P Waszak1, B Thébaud

  • 1Service de Réanimation, Soins Intensifs et Médecine Néonatals, 10 Rue du Dr Heydenreich, 54042 Nancy cedex, France. bthebaud@ualberta.ca

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|July 19, 2011
PubMed
Summary
This summary is machine-generated.

Mesenchymal stem cells (MSCs) show promise for treating bronchopulmonary dysplasia (BPD), a chronic lung disease in premature infants. Bone marrow-derived MSCs effectively prevent arrested lung development in BPD models, offering a potential regenerative therapy.

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Related Experiment Videos

Last Updated: May 31, 2026

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease
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Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease

Published on: April 12, 2021

Isolation of CD146+ Resident Lung Mesenchymal Stromal Cells from Rat Lungs
09:47

Isolation of CD146+ Resident Lung Mesenchymal Stromal Cells from Rat Lungs

Published on: June 17, 2016

Isolation & Characterization of Hoechstlow CD45negative Mouse Lung Mesenchymal Stem Cells
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Isolation & Characterization of Hoechstlow CD45negative Mouse Lung Mesenchymal Stem Cells

Published on: October 26, 2011

Area of Science:

  • Neonatology
  • Regenerative Medicine
  • Pulmonology

Context:

  • Survival rates for extremely premature newborns have improved due to advancements in perinatal care.
  • Infants born before 28 weeks gestation are at high risk for bronchopulmonary dysplasia (BPD).
  • BPD is characterized by arrested alveolar development and current therapies have limited efficacy.

Purpose:

  • To review the therapeutic potential of mesenchymal stem cells (MSCs) for treating BPD.
  • To summarize the mechanisms of action, particularly paracrine effects, of MSCs in lung development.
  • To highlight the promise of cell-based therapies in regenerative medicine for respiratory disorders.

Summary:

  • Mesenchymal stem cells (MSCs) demonstrate therapeutic benefits in various diseases, including respiratory disorders.
  • Bone marrow-derived MSCs have shown efficacy in preventing lung development arrest in an oxygen-induced BPD model.
  • This review consolidates current knowledge on MSC properties and their paracrine mechanisms relevant to BPD.

Impact:

  • Cell-based therapies, specifically MSCs, offer a promising avenue for novel regenerative treatments for BPD.
  • Understanding MSC mechanisms can lead to improved therapeutic strategies for chronic lung disease in premature infants.
  • This research supports the development of innovative treatments to mitigate the long-term respiratory complications in extremely premature neonates.