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Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease
09:45

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease

Published on: April 12, 2021

[Lung development and mesenchymal stem cells]

P Waszak1, B Thébaud

  • 1Service de Réanimation, Soins Intensifs et Médecine Néonatals, 10 Rue du Dr Heydenreich, 54042 Nancy cedex, France. bthebaud@ualberta.ca

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|July 19, 2011
PubMed

Insights

Mesenchymal stem cells (MSCs) show promise for treating bronchopulmonary dysplasia (BPD), a chronic lung disease in premature infants. Bone marrow-derived MSCs effectively prevent arrested lung development in BPD models, offering a potential regenerative therapy.

Area of Science:

  • Neonatology
  • Regenerative Medicine
  • Pulmonology

Context:

  • Survival rates for extremely premature newborns have improved due to advancements in perinatal care.
  • Infants born before 28 weeks gestation are at high risk for bronchopulmonary dysplasia (BPD).
  • BPD is characterized by arrested alveolar development and current therapies have limited efficacy.

Purpose:

  • To review the therapeutic potential of mesenchymal stem cells (MSCs) for treating BPD.
  • To summarize the mechanisms of action, particularly paracrine effects, of MSCs in lung development.
  • To highlight the promise of cell-based therapies in regenerative medicine for respiratory disorders.

Summary:

  • Mesenchymal stem cells (MSCs) demonstrate therapeutic benefits in various diseases, including respiratory disorders.
  • Bone marrow-derived MSCs have shown efficacy in preventing lung development arrest in an oxygen-induced BPD model.
  • This review consolidates current knowledge on MSC properties and their paracrine mechanisms relevant to BPD.

Impact:

  • Cell-based therapies, specifically MSCs, offer a promising avenue for novel regenerative treatments for BPD.
  • Understanding MSC mechanisms can lead to improved therapeutic strategies for chronic lung disease in premature infants.
  • This research supports the development of innovative treatments to mitigate the long-term respiratory complications in extremely premature neonates.

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