Related Experiment Video
Updated: Apr 21, 2026

Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding
Published on: February 26, 2015
Aging skin: histology, physiology, and pathology
Jeannie Khavkin1, David A F Ellis
1Division of Facial Plastic Surgery, Department of Otolaryngology-Head and Neck Surgery, University of Toronto, R. Fraser Elliott Building, 190 Elizabeth Street, Room 3S-438, Toronto, ON M5G 2N2, Canada. jkhavkin@gmail.com
Abstract:
Skin is a complex organ covering the entire surface of the body. Aged skin is characterized by appearance of wrinkles, laxity, and pigmentary irregularities. These changes occur under the influence of intrinsic and extrinsic factors, with sun exposure being the most deleterious to the skin. Skin changes associated with aging are the focus of many surgical and nonsurgical procedures aimed to improve the appearance of skin. Knowledge of skin histology and physiology will deepen the understanding of cutaneous changes associated with aging and will promote optimal cosmetic and functional patient outcomes.
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