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Dispersion of Nanomaterials in Aqueous Media: Towards Protocol Optimization
Published on: December 25, 2017
Dissolution enhancement of quercetin through nanofabrication, complexation, and solid dispersion
1School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore, Singapore.
Colloids and Surfaces. B, Biointerfaces
|July 19, 2011
Summary
This study enhanced quercetin dissolution using nanoparticles, complexes, and solid dispersions via evaporative precipitation of nanosuspension (EPN). Formulations significantly improved quercetin
Area of Science:
- Pharmaceutical Technology
- Materials Science
Background:
- Poor water solubility of drugs like quercetin limits bioavailability.
- Nanoparticle fabrication, complexation, and solid dispersion are strategies to enhance drug dissolution.
Purpose of the Study:
- To improve the dissolution rate of quercetin, a poorly water-soluble antioxidant.
- To investigate nanoparticle, complex, and solid dispersion formulations using evaporative precipitation of nanosuspension (EPN).
Main Methods:
- Evaporative precipitation of nanosuspension (EPN) was used to create quercetin nanoparticles.
- Quercetin was formulated into inclusion complexes with β-cyclodextrin and solid dispersions with polyvinylpyrrolidone and pluronic F127.
- Particle characteristics and dissolution rates were analyzed.
Main Results:
- Hexane as an antisolvent yielded the smallest quercetin nanoparticles (220 nm) at optimal conditions.
- EPN-prepared nanoparticles, complexes, and solid dispersions showed significantly higher dissolution rates than raw quercetin.
- Solid dispersions exhibited better dissolution than complexes at lower carrier concentrations.
Conclusions:
- Evaporative precipitation of nanosuspension is effective for enhancing quercetin dissolution.
- Nanoparticles, complexes, and solid dispersions offer improved bioavailability for poorly soluble drugs.
- Diffusion is the primary drug release mechanism from these formulations.
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