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Related Experiment Video

Updated: May 31, 2026

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Published on: February 6, 2015

Identifying differences between biochemical failure and cure: incidence rates and predictors.

Frank A Vicini¹, Chirag Shah, Larry Kestin

¹Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI 48073, USA. fvicini@beaumont.edu

International Journal of Radiation Oncology, Biology, Physics

|July 19, 2011

Summary

Long-term follow-up is crucial for prostate cancer patients treated with radiation therapy, as biochemical failure rates don't stabilize until after 10 years. Prostate-specific antigen nadir and time to nadir are key indicators of treatment success.

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Last Updated: May 31, 2026

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Published on: February 6, 2015

Area of Science:

Oncology
Radiation Oncology
Urology

Background:

Prostate cancer treatment efficacy requires understanding long-term outcomes.
Evaluating biochemical cure (BC) after radiation therapy (RT) is essential for patient management.

Purpose of the Study:

To estimate the time to achieve biochemical cure (BC) post-radiation therapy (RT) for prostate cancer.
To identify variables associated with long-term treatment efficacy and biochemical failure (BF).

Main Methods:

Analysis of 2,100 patients with localized prostate carcinoma treated with RT (external-beam, brachytherapy, or combined).
Biochemical failure (BF) defined using the Phoenix criteria.
Median follow-up of 8.6 years.

Main Results:

32.6% of patients experienced biochemical failure (BF).
Median time to BF varied by risk group (low: 6.0 years, intermediate: 5.6 years, high: 4.5 years).
Prostate-specific antigen nadir and time to nadir were significantly associated with 10-year BC.

Conclusions:

Biochemical failure (BF) rates in prostate cancer patients treated with RT do not plateau until after 10 years.
Extended patient follow-up is necessary to accurately assess long-term treatment outcomes.
Prostate-specific antigen nadir and time to nadir are the strongest predictors of long-term biochemical cure (BC).