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Gatekeepers for Piwi-piRNA complexes to enter the nucleus

Hirotsugu Ishizu1, Akihiro Nagao, Haruhiko Siomi

  • 1Department of Molecular Biology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan.

Current Opinion in Genetics & Development
|July 19, 2011
PubMed
Summary

Small silencing RNAs called piRNAs suppress transposable elements in Drosophila. These piRNAs are processed independently of Dicer and transported to the nucleus to maintain genome integrity during germline development.

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