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Related Experiment Video

Updated: May 31, 2026

Transverse Aortic Constriction in Mice
08:25

Transverse Aortic Constriction in Mice

Published on: April 21, 2010

Variable phenotype in murine transverse aortic constriction.

Selma F Mohammed1, Jimmy R Storlie, Elise A Oehler

  • 1Cardiorenal Research Laboratory, Mayo Clinic, Rochester, MN 55905, USA.

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
|July 19, 2011
PubMed
Summary

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Transverse aortic constriction (TAC) in mice causes variable cardiac changes. Echocardiography at 3 weeks can identify heart failure (HF) versus compensated left ventricular hypertrophy (LVH) in TAC mice.

Area of Science:

  • Cardiovascular Research
  • Animal Models
  • Cardiac Physiology

Background:

  • Transverse aortic constriction (TAC) is a common mouse model for pressure overload-induced cardiac hypertrophy and heart failure (HF).
  • The inherent variability within the TAC model is not well-defined, impacting study reproducibility.
  • A need exists for a reliable method to distinguish HF from compensated left ventricular hypertrophy (LVH) post-TAC.

Purpose of the Study:

  • To characterize the variability of the TAC model in mice.
  • To establish a noninvasive echocardiographic method for prospectively identifying HF versus compensated LVH.

Main Methods:

  • C57BL/6J mice underwent TAC or sham surgery, followed by echocardiography at 3 and 9 weeks.
  • Echocardiographic parameters and invasive measurements (LV systolic pressure) were assessed.

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Last Updated: May 31, 2026

Transverse Aortic Constriction in Mice
08:25

Transverse Aortic Constriction in Mice

Published on: April 21, 2010

A Closed-chest Model to Induce Transverse Aortic Constriction in Mice
08:10

A Closed-chest Model to Induce Transverse Aortic Constriction in Mice

Published on: April 5, 2018

Minimally Invasive Transverse Aortic Constriction in Mice
07:40

Minimally Invasive Transverse Aortic Constriction in Mice

Published on: March 14, 2017

  • Heart failure was defined by lung-to-body weight ratio exceeding the upper limit of sham controls.

    • Main Results:

    • TAC mice exhibited increased transverse aortic velocity, LV pressure, and LV weight, with decreased ejection fraction (EF) compared to sham controls.
    • Only 28% of TAC mice developed overt HF.
    • Echocardiographic measurements of EF and LV mass at 3 weeks post-TAC predicted the presence of HF at later time points.

    Conclusions:

    • The TAC model in wild-type mice yields a variable cardiac phenotype.
    • Significant abnormalities in LV mass and EF at 3 weeks post-TAC are indicative of subsequent HF.
    • These findings aid in the design and interpretation of murine cardiovascular studies.