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[Correlation between serum growth differentiation factor-15 and TIMI risk scores in patients with unstable angina
Ming-yao Deng1, Guo-ping Wu, Xu-xia Feng
1Department of Cardiology, Sanya Peoples Hospital, Sanya 572000, China.
Objective:
To explore the correlation between serum levels of growth differentiation factor-15 (GDF-15) and Thrombolysis in Myocardial Infarction (TIMI) risk scores in patients with unstable angina pectoris (UA).
Methods:
The serum levels of GDF-15 in 97 patients with UA and 30 healthy volunteers were measured using enzyme-linked immunosorbent assay (ELISA) and compared between 3 patient groups with different TIMI scores to analyze relationship between serum GDF-15 levels and TIMI risk scores.
Results:
The serum levels of GDF-15 in UA patients were significantly higher than those in the healthy volunteers (P<0.01). GDF-15 levels also differed significantly between patients with different TIMI scores (P<0.01), and showed a significant positive correlation to TIMI risk scores.
Conclusion:
Serum levels of GDF-15 can be used as an index for evaluating the severity of UA.
