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Updated: May 31, 2026

A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection
Published on: June 15, 2018
Clinical and infection control implications of Clostridium difficile infection with negative enzyme immunoassay for
Dubert M Guerrero1, Christina Chou, Lucy A Jury
1Department of Infectious Diseases, University Hospitals of Cleveland, OH, USA.
Abstract:
In a prospective study of 132 patients with a diagnosis of Clostridium difficile infection (CDI) by polymerase chain reaction, 43 (32%) had enzyme immunoassay (EIA) results negative for toxin. EIA-negative patients with CDI did not differ in clinical presentation from EIA-positive patients and presented a similar risk for transmission of spores.
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